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differentiation 44 cd44  (Cell Signaling Technology Inc)


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    Cell Signaling Technology Inc differentiation 44 cd44
    Network-based hub gene screening and expression validation in OSCC. (A) Top 10 hub candidates ranked by betweenness centrality. (B) Top 10 hub candidates ranked by degree centrality. (C) Intersection of two rankings identifying CCNA2, <t>CD44,</t> and STAT1 as shared hub genes. (D–F) Expression of CCNA2, <t>CD44,</t> and STAT1 in GSE30784 . (G–I) Expression of CCNA2, <t>CD44,</t> and STAT1 in GSE9844 .
    Differentiation 44 Cd44, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/differentiation 44 cd44/product/Cell Signaling Technology Inc
    Average 86 stars, based on 1 article reviews
    differentiation 44 cd44 - by Bioz Stars, 2026-05
    86/100 stars

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    1) Product Images from "Integrated network analysis and experimental validation identify CCNA2, CD44, and STAT1 as clinically relevant hub genes in oral squamous cell carcinoma"

    Article Title: Integrated network analysis and experimental validation identify CCNA2, CD44, and STAT1 as clinically relevant hub genes in oral squamous cell carcinoma

    Journal: Frontiers in Molecular Biosciences

    doi: 10.3389/fmolb.2026.1748821

    Network-based hub gene screening and expression validation in OSCC. (A) Top 10 hub candidates ranked by betweenness centrality. (B) Top 10 hub candidates ranked by degree centrality. (C) Intersection of two rankings identifying CCNA2, CD44, and STAT1 as shared hub genes. (D–F) Expression of CCNA2, CD44, and STAT1 in GSE30784 . (G–I) Expression of CCNA2, CD44, and STAT1 in GSE9844 .
    Figure Legend Snippet: Network-based hub gene screening and expression validation in OSCC. (A) Top 10 hub candidates ranked by betweenness centrality. (B) Top 10 hub candidates ranked by degree centrality. (C) Intersection of two rankings identifying CCNA2, CD44, and STAT1 as shared hub genes. (D–F) Expression of CCNA2, CD44, and STAT1 in GSE30784 . (G–I) Expression of CCNA2, CD44, and STAT1 in GSE9844 .

    Techniques Used: Expressing, Biomarker Discovery

    Validation and characterization of hub genes in TCGA cohort. (A–C) mRNA expression of CCNA2, CD44 and STAT1 in TCGA OSCC vs. normal tissues. (D–F) Kaplan–Meier overall survival curves stratified by CCNA2, CD44 and STAT1 expression. (G–I) GSEA enrichment plots for CCNA2, CD44 and STAT1.
    Figure Legend Snippet: Validation and characterization of hub genes in TCGA cohort. (A–C) mRNA expression of CCNA2, CD44 and STAT1 in TCGA OSCC vs. normal tissues. (D–F) Kaplan–Meier overall survival curves stratified by CCNA2, CD44 and STAT1 expression. (G–I) GSEA enrichment plots for CCNA2, CD44 and STAT1.

    Techniques Used: Biomarker Discovery, Expressing

    Prognostic nomogram and diagnostic performance of CCNA2, CD44 and STAT1. (A) Nomogram model based on CCNA2, CD44 and STAT1. (B) Calibration curve of the nomogram for 1-year survival prediction. (C) ROC curves of CCNA2, CD44 and STAT1 in GSE30784 . (D) ROC curves of CCNA2, CD44 and STAT1 in GSE9844 . (E) ROC curves of CCNA2, CD44 and STAT1 in TCGA.
    Figure Legend Snippet: Prognostic nomogram and diagnostic performance of CCNA2, CD44 and STAT1. (A) Nomogram model based on CCNA2, CD44 and STAT1. (B) Calibration curve of the nomogram for 1-year survival prediction. (C) ROC curves of CCNA2, CD44 and STAT1 in GSE30784 . (D) ROC curves of CCNA2, CD44 and STAT1 in GSE9844 . (E) ROC curves of CCNA2, CD44 and STAT1 in TCGA.

    Techniques Used: Diagnostic Assay

    Experimental validation of CCNA2, CD44 and STAT1 expression in OSCC tissues and cell lines. (A) Representative IHC staining of CCNA2, CD44 and STAT1 in control and OSCC tissues. (B–D) Quantification of IHC staining index for CCNA2, CD44 and STAT1 in human oral tissues. (E–G) qPCR analysis of CCNA2, CD44 and STAT1 mRNA levels in human oral tissues. (H–J) qPCR analysis of CCNA2, CD44 and STAT1 mRNA levels in normal versus OSCC cell lines. (K,L) qPCR analysis of CRNN mRNA expression in human oral tissues and cell lines. Data are presented as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001.
    Figure Legend Snippet: Experimental validation of CCNA2, CD44 and STAT1 expression in OSCC tissues and cell lines. (A) Representative IHC staining of CCNA2, CD44 and STAT1 in control and OSCC tissues. (B–D) Quantification of IHC staining index for CCNA2, CD44 and STAT1 in human oral tissues. (E–G) qPCR analysis of CCNA2, CD44 and STAT1 mRNA levels in human oral tissues. (H–J) qPCR analysis of CCNA2, CD44 and STAT1 mRNA levels in normal versus OSCC cell lines. (K,L) qPCR analysis of CRNN mRNA expression in human oral tissues and cell lines. Data are presented as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001.

    Techniques Used: Biomarker Discovery, Expressing, Immunohistochemistry, Control



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    Image Search Results


    Network-based hub gene screening and expression validation in OSCC. (A) Top 10 hub candidates ranked by betweenness centrality. (B) Top 10 hub candidates ranked by degree centrality. (C) Intersection of two rankings identifying CCNA2, CD44, and STAT1 as shared hub genes. (D–F) Expression of CCNA2, CD44, and STAT1 in GSE30784 . (G–I) Expression of CCNA2, CD44, and STAT1 in GSE9844 .

    Journal: Frontiers in Molecular Biosciences

    Article Title: Integrated network analysis and experimental validation identify CCNA2, CD44, and STAT1 as clinically relevant hub genes in oral squamous cell carcinoma

    doi: 10.3389/fmolb.2026.1748821

    Figure Lengend Snippet: Network-based hub gene screening and expression validation in OSCC. (A) Top 10 hub candidates ranked by betweenness centrality. (B) Top 10 hub candidates ranked by degree centrality. (C) Intersection of two rankings identifying CCNA2, CD44, and STAT1 as shared hub genes. (D–F) Expression of CCNA2, CD44, and STAT1 in GSE30784 . (G–I) Expression of CCNA2, CD44, and STAT1 in GSE9844 .

    Article Snippet: Primary antibodies against Cyclin A2 (CCNA2) (Abcam, ab181973), Cluster of Differentiation 44 (CD44) (Cell Signaling Technology, #3570), and Signal Transducer and Activator of Transcription 1 (STAT1) (Proteintech, 10144-2-AP) were applied, followed by HRP-conjugated secondary antibodies and DAB detection with hematoxylin counterstaining.

    Techniques: Expressing, Biomarker Discovery

    Validation and characterization of hub genes in TCGA cohort. (A–C) mRNA expression of CCNA2, CD44 and STAT1 in TCGA OSCC vs. normal tissues. (D–F) Kaplan–Meier overall survival curves stratified by CCNA2, CD44 and STAT1 expression. (G–I) GSEA enrichment plots for CCNA2, CD44 and STAT1.

    Journal: Frontiers in Molecular Biosciences

    Article Title: Integrated network analysis and experimental validation identify CCNA2, CD44, and STAT1 as clinically relevant hub genes in oral squamous cell carcinoma

    doi: 10.3389/fmolb.2026.1748821

    Figure Lengend Snippet: Validation and characterization of hub genes in TCGA cohort. (A–C) mRNA expression of CCNA2, CD44 and STAT1 in TCGA OSCC vs. normal tissues. (D–F) Kaplan–Meier overall survival curves stratified by CCNA2, CD44 and STAT1 expression. (G–I) GSEA enrichment plots for CCNA2, CD44 and STAT1.

    Article Snippet: Primary antibodies against Cyclin A2 (CCNA2) (Abcam, ab181973), Cluster of Differentiation 44 (CD44) (Cell Signaling Technology, #3570), and Signal Transducer and Activator of Transcription 1 (STAT1) (Proteintech, 10144-2-AP) were applied, followed by HRP-conjugated secondary antibodies and DAB detection with hematoxylin counterstaining.

    Techniques: Biomarker Discovery, Expressing

    Prognostic nomogram and diagnostic performance of CCNA2, CD44 and STAT1. (A) Nomogram model based on CCNA2, CD44 and STAT1. (B) Calibration curve of the nomogram for 1-year survival prediction. (C) ROC curves of CCNA2, CD44 and STAT1 in GSE30784 . (D) ROC curves of CCNA2, CD44 and STAT1 in GSE9844 . (E) ROC curves of CCNA2, CD44 and STAT1 in TCGA.

    Journal: Frontiers in Molecular Biosciences

    Article Title: Integrated network analysis and experimental validation identify CCNA2, CD44, and STAT1 as clinically relevant hub genes in oral squamous cell carcinoma

    doi: 10.3389/fmolb.2026.1748821

    Figure Lengend Snippet: Prognostic nomogram and diagnostic performance of CCNA2, CD44 and STAT1. (A) Nomogram model based on CCNA2, CD44 and STAT1. (B) Calibration curve of the nomogram for 1-year survival prediction. (C) ROC curves of CCNA2, CD44 and STAT1 in GSE30784 . (D) ROC curves of CCNA2, CD44 and STAT1 in GSE9844 . (E) ROC curves of CCNA2, CD44 and STAT1 in TCGA.

    Article Snippet: Primary antibodies against Cyclin A2 (CCNA2) (Abcam, ab181973), Cluster of Differentiation 44 (CD44) (Cell Signaling Technology, #3570), and Signal Transducer and Activator of Transcription 1 (STAT1) (Proteintech, 10144-2-AP) were applied, followed by HRP-conjugated secondary antibodies and DAB detection with hematoxylin counterstaining.

    Techniques: Diagnostic Assay

    Experimental validation of CCNA2, CD44 and STAT1 expression in OSCC tissues and cell lines. (A) Representative IHC staining of CCNA2, CD44 and STAT1 in control and OSCC tissues. (B–D) Quantification of IHC staining index for CCNA2, CD44 and STAT1 in human oral tissues. (E–G) qPCR analysis of CCNA2, CD44 and STAT1 mRNA levels in human oral tissues. (H–J) qPCR analysis of CCNA2, CD44 and STAT1 mRNA levels in normal versus OSCC cell lines. (K,L) qPCR analysis of CRNN mRNA expression in human oral tissues and cell lines. Data are presented as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001.

    Journal: Frontiers in Molecular Biosciences

    Article Title: Integrated network analysis and experimental validation identify CCNA2, CD44, and STAT1 as clinically relevant hub genes in oral squamous cell carcinoma

    doi: 10.3389/fmolb.2026.1748821

    Figure Lengend Snippet: Experimental validation of CCNA2, CD44 and STAT1 expression in OSCC tissues and cell lines. (A) Representative IHC staining of CCNA2, CD44 and STAT1 in control and OSCC tissues. (B–D) Quantification of IHC staining index for CCNA2, CD44 and STAT1 in human oral tissues. (E–G) qPCR analysis of CCNA2, CD44 and STAT1 mRNA levels in human oral tissues. (H–J) qPCR analysis of CCNA2, CD44 and STAT1 mRNA levels in normal versus OSCC cell lines. (K,L) qPCR analysis of CRNN mRNA expression in human oral tissues and cell lines. Data are presented as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001.

    Article Snippet: Primary antibodies against Cyclin A2 (CCNA2) (Abcam, ab181973), Cluster of Differentiation 44 (CD44) (Cell Signaling Technology, #3570), and Signal Transducer and Activator of Transcription 1 (STAT1) (Proteintech, 10144-2-AP) were applied, followed by HRP-conjugated secondary antibodies and DAB detection with hematoxylin counterstaining.

    Techniques: Biomarker Discovery, Expressing, Immunohistochemistry, Control